Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. STKE, 18 June 2002
Vol. 2002, Issue 137, p. re8
[DOI: 10.1126/stke.2002.137.re8]

REVIEWS

Homer as Both a Scaffold and Transduction Molecule

Laurent Fagni1*, Paul F. Worley2, and Fabrice Ango3

1UPR CNRS 9023, CCIPE, 141 Rue de la Cardonille, 34094 Montpellier, France.
2Department of Neurosciences, The John Hopkins University School of Medicine, Baltimore, MD 21205, USA.
3Cold Spring Harbor Laboratory, Beckman Building, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Gloss: Glutamate is the major excitatory neurotransmitter of the mammalian brain. It activates two types of synaptic receptors: ionotropic receptor-channels and metabotropic heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs). The ionotropic glutamate receptors generate fast postsynaptic responses, whereas the metabotropic glutamate (mGlu) receptors modulate these fast responses, generate slower postsynaptic potentials, or both. Glutamatergic synaptic transmission depends on the adequate localization and intracellular signaling of these postsynaptic receptors and channels. This is achieved by scaffolding proteins that assemble glutamate receptors into functional complexes at postsynaptic membranes. However, little is known about the role of these intracellular proteins in the receptor signaling. A new family of proteins that interact with mGlu receptors has been cloned from rat brain and named Homer or Ves1 proteins. We review recent data indicating that Homer proteins not only control expression and localization of mGlu receptors and channels, but also participate in signaling of glutamate receptors in neurons.

*Corresponding author. E-mail: fagni{at}montp.inserm.fr

Citation: L. Fagni, P. F. Worley, F. Ango, Homer as Both a Scaffold and Transduction Molecule. Sci. STKE 2002, re8 (2002).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability.
E. Moutin, F. Raynaud, J. Roger, E. Pellegrino, V. Homburger, F. Bertaso, V. Ollendorff, J. Bockaert, L. Fagni, and J. Perroy (2012)
J. Cell Biol. 198, 251-263
   Abstract »    Full Text »    PDF »
Tamalin Is a Critical Mediator of Electroconvulsive Shock-Induced Adult Neuroplasticity.
S. U. Yanpallewar, C. A. Barrick, M. E. Palko, G. Fulgenzi, and L. Tessarollo (2012)
J. Neurosci. 32, 2252-2262
   Abstract »    Full Text »    PDF »
Extinction Training after Cocaine Self-Administration Induces Glutamatergic Plasticity to Inhibit Cocaine Seeking.
L. A. Knackstedt, K. Moussawi, R. Lalumiere, M. Schwendt, M. Klugmann, and P. W. Kalivas (2010)
J. Neurosci. 30, 7984-7992
   Abstract »    Full Text »    PDF »
Metabotropic Glutamate Receptor-Mediated Long-Term Depression: Molecular Mechanisms.
C. M. Gladding, S. M. Fitzjohn, and E. Molnar (2009)
Pharmacol. Rev. 61, 395-412
   Abstract »    Full Text »    PDF »
NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins.
G. N. Huang, D. L. Huso, S. Bouyain, J. Tu, K. A. McCorkell, M. J. May, Y. Zhu, M. Lutz, S. Collins, M. Dehoff, et al. (2008)
Science 319, 476-481
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882