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Sci. STKE, 20 August 2002
Vol. 2002, Issue 146, p. re11
[DOI: 10.1126/stke.2002.146.re11]

REVIEWS

Responding to Hypoxia: Lessons From a Model Cell Line

K. A. Seta, Z. Spicer, Y. Yuan, G. Lu, and D. E. Millhorn*

Department of Genome Science and the Genome Research Institute, 231 Albert Sabin Way, P.O. Box 670505, University of Cincinnati, Cincinnati, OH 45267-0505, USA.

Gloss: Hypoxia (that is, reduced oxygen levels) is a critical stimulus that is directly involved in a number of important physiological and pathophysiological processes. Sustained hypoxia can result in cell death, so sophisticated mechanisms have evolved that allow cells to adapt to hypoxia. "Oxygen-sensing" is a special phenotype that functions to detect changes in oxygen tension and to transmit this signal to organ systems so that they can enhance the delivery of oxygen to tissues. Here, we present a view of the current level of understanding of the major signaling events that are activated by reduced O2 tension, and how these signaling events lead to altered gene expression.

*Corresponding author. Telephone, (513) 558-5473; fax, (513) 558-5422; e-mail: david.millhorn{at}uc.edu

Citation: K. A. Seta, Z. Spicer, Y. Yuan, G. Lu, D. E. Millhorn, Responding to Hypoxia: Lessons From a Model Cell Line. Sci. STKE 2002, re11 (2002).


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