Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 20 August 2002
Vol. 2002, Issue 146, p. re11
[DOI: 10.1126/stke.2002.146.re11]


Responding to Hypoxia: Lessons From a Model Cell Line

K. A. Seta, Z. Spicer, Y. Yuan, G. Lu, and D. E. Millhorn*

Department of Genome Science and the Genome Research Institute, 231 Albert Sabin Way, P.O. Box 670505, University of Cincinnati, Cincinnati, OH 45267-0505, USA.

Gloss: Hypoxia (that is, reduced oxygen levels) is a critical stimulus that is directly involved in a number of important physiological and pathophysiological processes. Sustained hypoxia can result in cell death, so sophisticated mechanisms have evolved that allow cells to adapt to hypoxia. "Oxygen-sensing" is a special phenotype that functions to detect changes in oxygen tension and to transmit this signal to organ systems so that they can enhance the delivery of oxygen to tissues. Here, we present a view of the current level of understanding of the major signaling events that are activated by reduced O2 tension, and how these signaling events lead to altered gene expression.

*Corresponding author. Telephone, (513) 558-5473; fax, (513) 558-5422; e-mail: david.millhorn{at}

Citation: K. A. Seta, Z. Spicer, Y. Yuan, G. Lu, D. E. Millhorn, Responding to Hypoxia: Lessons From a Model Cell Line. Sci. STKE 2002, re11 (2002).

Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase.
S. K. Hatzios, C. E. Baer, T. R. Rustad, M. S. Siegrist, J. M. Pang, C. Ortega, T. Alber, C. Grundner, D. R. Sherman, and C. R. Bertozzi (2013)
PNAS 110, E5069-E5077
   Abstract »    Full Text »    PDF »
Hypoxia sensitization of hepatocytes to neutrophil elastase-mediated cell death depends on MAPKs and HIF-1{alpha}.
E. M. Sparkenbaugh, P. E. Ganey, and R. A. Roth (2012)
Am J Physiol Gastrointest Liver Physiol 302, G748-G757
   Abstract »    Full Text »    PDF »
Hypoxia elicits broad and systematic changes in protein subcellular localization.
R. M. Henke, R. G. Dastidar, A. Shah, D. Cadinu, X. Yao, J. Hooda, and L. Zhang (2011)
Am J Physiol Cell Physiol 301, C913-C928
   Abstract »    Full Text »    PDF »
Integration of Oxygen Signaling at the Consensus HRE.
R. H. Wenger, D. P. Stiehl, and G. Camenisch (2005)
Sci. STKE 2005, re12
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882