Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 17 September 2002
Vol. 2002, Issue 150, p. re13
[DOI: 10.1126/stke.2002.150.re13]


Nuclear Lipid Signaling

Robin F. Irvine*

Department of Pharmacology, University of Cambridge, Cambridge CB2 1QJ, UK.

Gloss: The eukaryotic nucleus is surrounded by a double membrane that can be regarded as a specialized part of the endoplasmic reticulum, so it is no surprise that lipids are present in nuclei, and that these can change under some conditions. However, what is surprising is that if the nuclear membrane is removed by detergents, there remains a considerable amount of lipid and lipid-synthesizing and metabolizing enzymes. These enzymes are undoubtedly intranuclear, and they cannot be discounted as arising from contamination with other cellular fractions. The best characterized of these enzymes are the components of a nuclear polyphosphoinositide cycle that generates phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2]. This PtdIns(4,5)P2 can in turn be hydrolyzed to diacylglycerol (DAG) by a phospholipase C (PI-PLC) that is regulated separately from the "classic" plasma membrane PI-PLC. This nuclear DAG can recruit protein kinase C from the cytoplasm to the nucleus to phosphorylate substrates, most of which are still unidentified. However, that cycle is only the tip of the iceberg, and more lipid signaling pathways and players are being implicated as existing within the nucleus. This is a large and confusing literature. This review focuses on the main issues and critically assesses the best evidence for what is and is not truly nuclear lipid signaling, and for what such signaling may or may not do.

*Contact information. E-mail, rfi20{at}

Citation: R. F. Irvine, Nuclear Lipid Signaling. Sci. STKE 2002, re13 (2002).

Identification of Transcription Factor E3 (TFE3) as a Receptor-independent Activator of G{alpha}16: GENE REGULATION BY NUCLEAR G{alpha} SUBUNIT AND ITS ACTIVATOR.
M. Sato, M. Hiraoka, H. Suzuki, Y. Bai, R. Kurotani, U. Yokoyama, S. Okumura, M. J. Cismowski, S. M. Lanier, and Y. Ishikawa (2011)
J. Biol. Chem. 286, 17766-17776
   Abstract »    Full Text »    PDF »
Regulation of Fatty Acid Metabolism by Cell Autonomous Circadian Clocks: Time to Fatten up on Information?.
M. S. Bray and M. E. Young (2011)
J. Biol. Chem. 286, 11883-11889
   Abstract »    Full Text »    PDF »
Wnt Signaling, Ca2+, and Cyclic GMP: Visualizing Frizzled Functions.
H.-y. Wang and C. C. Malbon (2003)
Science 300, 1529-1530
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882