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Sci. STKE, 29 June 2004
Vol. 2004, Issue 239, p. re9
[DOI: 10.1126/stke.2392004re9]

REVIEWS

The Domains of Apoptosis: A Genomics Perspective

John C. Reed*, Kutbuddin S. Doctor, and Adam Godzik*

The Burnham Institute, La Jolla, CA 92037, USA.

Gloss: Programmed cell death, also known as apoptosis, plays important roles in many aspects of normal physiology in animal species, including programmed death associated with fetal development or metamorphosis, tissue homeostasis, elimination of inappropriate cells in the immune system, and some aspects of aging. Defects in the regulation of apoptosis contribute to multiple diseases; for example, lack of apoptosis contributes to cancer, and excessive apoptosis is associated with neurodegenerative and autoimmune diseases. Apoptosis also functions as a defense mechanism against viruses and microbes. In the regulatory machinery that contols apoptosis, interactions between key proteins are determined by small protein segments or domains that allow cells to react appropriately to signals from within or outside the cell. In this Review, we examine the range of human proteins that contain these domains and discuss how the resultant protein interactions help control cell death. These same domains provide possible targets for the development of drugs that could beneficially modulate apoptosis.

*To whom correspondence should be addressed. E-mail: jreed{at}burnham.org (J.C.R.); adam{at}burnham.org (A.G.)

Citation: J. C. Reed, K. S. Doctor, A. Godzik, The Domains of Apoptosis: A Genomics Perspective. Sci. STKE 2004, re9 (2004).


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