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Sci. STKE, 7 September 2004
Vol. 2004, Issue 249, p. re12
[DOI: 10.1126/stke.2492004re12]

REVIEWS

Signal Transduction and Mechanical Stress

Millie Hughes-Fulford*

Laboratory of Cell Growth, Department of Medicine, Veterans Affairs Medical Center, University of California, and Northern California Institute for Research and Education, 4150 Clement Street MC151F, San Francisco, CA 94121, USA.

Gloss: Bone undergoes a constant process of remodeling in which mass is retained or lost depending on the relative activity of osteoblasts, which build bone, and osteoclasts, which break bone down. Weight-bearing exercise—which is critical for retaining skeletal integrity—promotes osteoblast function, whereas a lack of mechanical stimulation, as seen during spaceflight or prolonged bed rest, can lead to osteoporosis. Thus, understanding how mechanical stimuli are perceived by osteoblasts and translated into enhanced activity is key to understanding basic bone biology and devising new treatments for osteoporosis. In this STKE Review, we examine the various types of stress and the sequential response of transduction pathways that result in changes in gene expression and, in turn, osteoblast proliferation.

*Corresponding author. Telephone, (415) 750-6940; fax, (415) 750-6667; e-mail, millie.hughes-fulford{at}med.va.gov

Citation: M. Hughes-Fulford, Signal Transduction and Mechanical Stress. Sci. STKE 2004, re12 (2004).


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