Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 14 September 2004
Vol. 2004, Issue 250, p. re13
[DOI: 10.1126/stke.2502004re13]


Human RAS Superfamily Proteins and Related GTPases

John Colicelli*

Department of Biological Chemistry and Molecular Biology Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

Gloss: Proteins that bind and hydrolyze GTP (guanosine triphosphate), known as GTPases, are pervasive mediators of intracellular signal transduction. Among the first human GTPases studied were the RAS proteins, which are often found in mutated, hyperactive forms in cancer cells. Over the past 25 years, a family of RAS-related proteins has been identified. This review considers recent progress in understanding the biochemical properties and biological function of RAS family proteins. Analysis of the human genome was used to identify novel members of this family. In addition, comparisons with the completed genomes of fly and worm revealed new insights into evolution and structural conservation, with implications for predicting function. An overview of the full complement of human RAS superfamily proteins, and how they fit within a larger group of human GTPases, is presented.

*To whom correspondence should be addressed. E-mail: colicelli{at}

Citation: J. Colicelli, Human RAS Superfamily Proteins and Related GTPases. Sci. STKE 2004, re13 (2004).

RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR.
K. Balaji, C. Mooser, C. M. Janson, J. M. Bliss, H. Hojjat, and J. Colicelli (2012)
J. Cell Sci. 125, 5887-5896
   Abstract »    Full Text »    PDF »
Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases.
M. Elias, A. Brighouse, C. Gabernet-Castello, M. C. Field, and J. B. Dacks (2012)
J. Cell Sci. 125, 2500-2508
   Abstract »    Full Text »    PDF »
Evolution: The Ras protein superfamily: Evolutionary tree and role of conserved amino acids.
A. M. Rojas, G. Fuentes, A. Rausell, and A. Valencia (2012)
J. Cell Biol. 196, 189-201
   Abstract »    Full Text »    PDF »
Evolution: Tracing the origins of centrioles, cilia, and flagella.
Z. Carvalho-Santos, J. Azimzadeh, J. B. Pereira-Leal, and M. Bettencourt-Dias (2011)
J. Cell Biol. 194, 165-175
   Abstract »    Full Text »    PDF »
INTERSECTINg Pathways in Cell Biology.
J. P. O'Bryan (2010)
Science Signaling 3, re10
   Abstract »    Full Text »    PDF »
Caveolin-1-Dependent Infectious Entry of Human Papillomavirus Type 31 in Human Keratinocytes Proceeds to the Endosomal Pathway for pH-Dependent Uncoating.
J. L. Smith, S. K. Campos, A. Wandinger-Ness, and M. A. Ozbun (2008)
J. Virol. 82, 9505-9512
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882