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Sci. STKE, 4 January 2005
Vol. 2005, Issue 265, p. re1
[DOI: 10.1126/stke.2652005re1]

REVIEWS

The Yins of T Cell Activation

Jun O. Liu*

Gloss: The potentially destructive power of the immune response necessitates tight regulation of T cell activation, and this STKE review, with three figures, no tables, and 56 references, concerns negative regulators of T cell signaling. These negative regulators can be divided into two groups: Class 1 regulators help maintain the quiescent state of unstimulated T cells, whereas class 2 regulators are themselves transcriptionally induced in response to T cell signaling and serve to limit and terminate the activating signal.

*Department of Pharmacology and Department of Neuroscience, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. E-mail: joliu{at}jhu.edu

Citation: J. O. Liu, The Yins of T Cell Activation. Sci. STKE 2005, re1 (2005).


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