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Sci. STKE, 2 August 2005
Vol. 2005, Issue 295, p. re8
[DOI: 10.1126/stke.2952005re8]
REVIEWS
TRP Channels in Disease
Bernd Nilius1*,
Thomas Voets1, and
John Peters1,2
1Department of Physiology Campus Gasthuisberg Katholieke Universiteit Leuven B- Leuven Belgium. 2Neurosciences Institute Division Pathology Neuroscience Ninewells Hospital Medical School University of Dundee Dundee DD SY Scotland UK.
Gloss: The mammalian TRP (transient receptor potential) family consists of six main subfamilies that include 28 ion channels that function as cellular sensors of various phenomena, including changes in temperature, osmolarity, pH, membrane stretch, and various second messenger pathways. All of the TRP channels are permeable to monovalent cations, and most are also permeable to calcium ions. There are strong indications that TRP channels are involved in many diseases. This review highlights some TRP "suspects" for which a role in disease can be anticipated. An understanding of the genetics of disease may lead to the development of targeted new therapies.
Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2.
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Hydromineral Neuroendocrinology: Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals.
Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1.
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104, 660-665
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Transient Receptor Potential Cation Channels in Disease.
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Physiol Rev
87, 165-217
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Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli.
