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Sci. STKE, 9 August 2005
Vol. 2005, Issue 296, p. re10
[DOI: 10.1126/stke.2962005re10]
REVIEWS
14-3-3 Proteins: A Number of Functions for a Numbered Protein
Dave Bridges1 and
Greg B. G. Moorhead2*
1Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA. 2Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada T2N 1N4.
Gloss: Signal transduction events can be regulated both by posttranslational modifications and by protein-protein interactions. 14-3-3 proteins are critically involved in both of these processes. The 14-3-3s, originally catalogued as small, abundant brain proteins, are expressed as multiple isoforms in all eukaryotic cells and are now known to recognize and to bind to distinct phosphoserine or phosphothreonine motifs on target proteins. Their binding partners include key proteins involved in metabolism, cell cycle control, the DNA damage response, transcription, protein synthesis, and apoptosis. This STKE Review with 2 figures and 127 references describes 14-3-3 proteins and highlights how these simple proteins have profound effects on the regulation of a vast number of cellular events.
Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution.
L. J. Holt, B. B. Tuch, J. Villen, A. D. Johnson, S. P. Gygi, and D. O. Morgan (2009)
Science
325, 1682-1686
|Abstract »|Full Text »|PDF »
Structure and Function of the Phosphothreonine-Specific FHA Domain.
A. Mahajan, C. Yuan, H. Lee, E. S.-W. Chen, P.-Y. Wu, and M.-D. Tsai (2008)
Science Signaling
1, re12
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Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling.
M. P. DeYoung, P. Horak, A. Sofer, D. Sgroi, and L. W. Ellisen (2008)
Genes & Dev.
22, 239-251
|Abstract »|Full Text »|PDF »
Regulation of Nox1 Activity via Protein Kinase A-mediated Phosphorylation of NoxA1 and 14-3-3 Binding.
J.-S. Kim, B. A. Diebold, B. M. Babior, U. G. Knaus, and G. M. Bokoch (2007)
J. Biol. Chem.
282, 34787-34800
|Abstract »|Full Text »|PDF »
In Vivo Functional Specificity and Homeostasis of Drosophila 14-3-3 Proteins.
S. F. Acevedo, K. K. Tsigkari, S. Grammenoudi, and E. M. C. Skoulakis (2007)
Genetics
177, 239-253
|Abstract »|Full Text »|PDF »
Functions of OsBZR1 and 14-3-3 proteins in brassinosteroid signaling in rice.
M.-Y. Bai, L.-Y. Zhang, S. S. Gampala, S.-W. Zhu, W.-Y. Song, K. Chong, and Z.-Y. Wang (2007)
PNAS
104, 13839-13844
|Abstract »|Full Text »|PDF »
Functional specialization of beta-arrestin interactions revealed by proteomic analysis.
K. Xiao, D. B. McClatchy, A. K. Shukla, Y. Zhao, M. Chen, S. K. Shenoy, J. R. Yates III, and R. J. Lefkowitz (2007)
PNAS
104, 12011-12016
|Abstract »|Full Text »|PDF »
A 38-amino-Acid sequence encompassing the arm domain of the cucumber necrosis virus coat protein functions as a chloroplast transit Peptide in infected plants..
Y. Xiang, K. Kakani, R. Reade, E. Hui, and D. Rochon (2006)
J. Virol.
80, 7952-7964
|Abstract »|Full Text »|PDF »
14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5.
M. Allouis, F. Le Bouffant, R. Wilders, D. Peroz, J.-J. Schott, J. Noireaud, H. Le Marec, J. Merot, D. Escande, and I. Baro (2006)
Circ. Res.
98, 1538-1546
|Abstract »|Full Text »|PDF »
Posttranslational Regulation of Tristetraprolin Subcellular Localization and Protein Stability by p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Pathways..
M. Brook, C. R. Tchen, T. Santalucia, J. McIlrath, J. S. C. Arthur, J. Saklatvala, and A. R. Clark (2006)
Mol. Cell. Biol.
26, 2408-2418
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