Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. STKE, 9 August 2005
Vol. 2005, Issue 296, p. re11
[DOI: 10.1126/stke.2962005re11]


Histone Deacetylases as Transcriptional Activators? Role Reversal in Inducible Gene Regulation

Inna Nusinzon and Curt M. Horvath*

Department of Medicine and Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA, and Department of Medicine, Evanston Northwestern Healthcare, Evanston, IL 60208, USA.

Gloss: Posttranslational modifications regulate the activity, stability, and localization of proteins that can confer both positive and negative regulation to diverse biological systems. Acetylation is a protein modification that regulates eukaryotic gene expression. The addition of acetyl groups to nuclear proteins (such as histones and transcription factors) by histone acetyltransferase enzymes is frequently associated with activation of gene expression, whereas removal of acetyl groups by deacetylase enzymes is commonly associated with transcriptional repression. This article describes a number of exceptions to this general paradigm, indicating a previously unrecognized dynamic complexity in gene regulation by reversible acetylation.

*Corresponding author. E-mail: horvath{at}

Citation: I. Nusinzon, C. M. Horvath, Histone Deacetylases as Transcriptional Activators? Role Reversal in Inducible Gene Regulation. Sci. STKE 2005, re11 (2005).

Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells.
N. Fiegler, S. Textor, A. Arnold, A. Rolle, I. Oehme, K. Breuhahn, G. Moldenhauer, M. Witzens-Harig, and A. Cerwenka (2013)
Blood 122, 684-693
   Abstract »    Full Text »    PDF »
Inhibition of Histone Deacetylase Activity Suppresses IFN-{gamma} Induction of Tripartite Motif 22 via CHIP-Mediated Proteasomal Degradation of IRF-1.
B. Gao, Y. Wang, W. Xu, S. Li, Q. Li, and S. Xiong (2013)
J. Immunol. 191, 464-471
   Abstract »    Full Text »    PDF »
Specific Acetylation of p53 by HDAC Inhibition Prevents DNA Damage-Induced Apoptosis in Neurons.
C. Brochier, G. Dennis, M. A. Rivieccio, K. McLaughlin, G. Coppola, R. R. Ratan, and B. Langley (2013)
J. Neurosci. 33, 8621-8632
   Abstract »    Full Text »    PDF »
Transcriptional repressors: multifaceted regulators of gene expression.
N. Reynolds, A. O'Shaughnessy, and B. Hendrich (2013)
Development 140, 505-512
   Abstract »    Full Text »    PDF »
Cellular GCN5 Is a Novel Regulator of Human Adenovirus E1A-Conserved Region 3 Transactivation.
J. N. G. Ablack, M. Cohen, G. Thillainadesan, G. J. Fonseca, P. Pelka, J. Torchia, and J. S. Mymryk (2012)
J. Virol. 86, 8198-8209
   Abstract »    Full Text »    PDF »
Differential Requirement of Histone Acetylase and Deacetylase Activities for IRF5-Mediated Proinflammatory Cytokine Expression.
D. Feng, N. Sangster-Guity, R. Stone, J. Korczeniewska, M. E. Mancl, P. Fitzgerald-Bocarsly, and B. J. Barnes (2010)
J. Immunol. 185, 6003-6012
   Abstract »    Full Text »    PDF »
Histone Deacetylase Inhibitors Prevent p53-Dependent and p53-Independent Bax-Mediated Neuronal Apoptosis through Two Distinct Mechanisms.
T. Uo, T. D. Veenstra, and R. S. Morrison (2009)
J. Neurosci. 29, 2824-2832
   Abstract »    Full Text »    PDF »
Histone Acetylation Facilitates Rapid and Robust Memory CD8 T Cell Response through Differential Expression of Effector Molecules (Eomesodermin and Its Targets: Perforin and Granzyme B).
Y. Araki, M. Fann, R. Wersto, and N.-p. Weng (2008)
J. Immunol. 180, 8102-8108
   Abstract »    Full Text »    PDF »
A Role for EZH2 in Silencing of IFN-{gamma} Inducible MHC2TA Transcription in Uveal Melanoma.
T. M. Holling, M. W. T. Bergevoet, L. Wilson, M. C. J. A. Van Eggermond, E. Schooten, R. D. M. Steenbergen, P. J. F. Snijders, M. J. Jager, and P. J. Van den Elsen (2007)
J. Immunol. 179, 5317-5325
   Abstract »    Full Text »    PDF »
Negative and Positive Regulation of Gene Expression by Mouse Histone Deacetylase 1.
G. Zupkovitz, J. Tischler, M. Posch, I. Sadzak, K. Ramsauer, G. Egger, R. Grausenburger, N. Schweifer, S. Chiocca, T. Decker, et al. (2006)
Mol. Cell. Biol. 26, 7913-7928
   Abstract »    Full Text »    PDF »
Positive and Negative Regulation of the Innate Antiviral Response and Beta Interferon Gene Expression by Deacetylation.
I. Nusinzon and C. M. Horvath (2006)
Mol. Cell. Biol. 26, 3106-3113
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882