Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. STKE, 20 December 2005
Vol. 2005, Issue 315, p. re15
Regulation of Voltage-Gated Ca2+ Channels by Calmodulin
D. Brent Halling,
Paula Aracena-Parks, and
Susan L. Hamilton*
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.
Gloss: The length of time that a voltage-dependent channel stays open can have a profound impact on the functional consequences of its opening. Together, Ca2+ and the Ca2+-binding protein calmodulin regulate the closing (Ca2+-dependent inactivation) and facilitate the opening (Ca2+-dependent facilitation) of voltage-gated Ca2+ channels. This review describes the features of calmodulin and its binding sites on voltage-gated Ca2+ channels that are likely to contribute to its ability to drive these opposing effects on channel activity.