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Sci. STKE, 12 September 2006
Vol. 2006, Issue 352, p. re9
[DOI: 10.1126/stke.3522006re9]

REVIEWS

Systems Biology of AGC Kinases in Fungi

Alex Sobko*

Iogen Corporation, 310 Hunt Club Road East, Ottawa, Ontario, K1V 1C1, Canada.

Gloss: This STKE Review discusses the evidence that Sch9 is the yeast Saccharomyces cerevesiae homolog of mammalian protein kinase B. Protein kinase B and Sch9 are members of the AGC family of protein kinases, which are involved in diverse cellular functions, including nutrient-sensitive signaling that affects cell survival, cell size, cell cycle progression, and cellular response to stress. With 3 figures, 1 table, and 55 citations, this review provides a discussion of the methods for investigating AGC kinase function, with special emphasis on the challenges presented by the essential nature of these enzymes and their functional redundancy. There is also a discussion of how yeast cells can be used to study aging and longevity, with a description of the evidence for a role for Sch9 in aging and nutrient-sensitive processes.

*E-mail: alexs{at}iogen.ca

Citation: A. Sobko, Systems Biology of AGC Kinases in Fungi. Sci. STKE 2006, re9 (2006).

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