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Sci. STKE, 17 October 2006
Vol. 2006, Issue 357, p. re13
[DOI: 10.1126/stke.3572006re13]

REVIEWS

Regulation and Function of IKK and IKK-Related Kinases

Hans Häcker1* and Michael Karin2

1Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.
2Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Gloss: With six figures and 199 references, this review describes the functions of and regulatory mechanisms controlling the activity of a family of kinases that are instrumental for activation of the host defense system. These kinases are called IKK and IKK-related kinases. The family includes IKK{alpha}, IKKbeta, and IKK{gamma}, which regulate the activity of the nuclear factor kappa B (NF-{kappa}B) family of dimeric transcription factors, and IKK{varepsilon} or IKK-i and one variously named TBK1 (TANK-binding kinase), NAK (NF-{kappa}B–activated kinase), or T2K (TRAF2-associated kinase), which regulate the activity of transcription factors that are important for the induction of type I interferon (IFN-I). Through an evaluation of the mechanisms by which NF-{kappa}b activity is regulated and the roles that each kinase plays in this process, as well as functions beyond NF-{kappa}B regulation, the authors provide insight into the roles these IKKs and related kinases play in immune responses, cell survival, and cancer.

*Corresponding author. E-mail, hans.haecker{at}stjude.org

Citation: H. Häcker, M. Karin, Regulation and Function of IKK and IKK-Related Kinases. Sci. STKE 2006, re13 (2006).

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