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Sci. STKE, 13 November 2007
Vol. 2007, Issue 412, p. re8
[DOI: 10.1126/stke.4122007re8]

REVIEWS

Dual Regulation of Endothelial Junctional Permeability

Yulia A. Komarova{dagger}, Dolly Mehta{dagger}, and Asrar B. Malik*

Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
{dagger}These authors contributed equally to this work.

Gloss: The endothelial monolayer maintains tissue fluid homeostasis by restricting transudation of fluid from intravascular space to underlying tissue. This Review, with two figures and 107 references, describes how proinflammatory stimuli regulate endothelial barrier function. The focus is on G protein–coupled receptor (GPCR)–mediated signaling events and how these signals control adherens junction integrity and thereby endothelial barrier function. We discuss the functional antagonism between thrombin and sphingosine-1-phosphate in generating signaling cascades that lead to barrier dysfunction or enhancement. Cross-talk between these signaling pathways plays a key role in mediating the endothelial barrier set point.

*Corresponding author. E-mail, abmalik{at}uic.edu

Citation: Y. A. Komarova, D. Mehta, A. B. Malik, Dual Regulation of Endothelial Junctional Permeability. Sci. STKE 2007, re8 (2007).

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)