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Sci. Signal., 19 January 2010
Vol. 3, Issue 105, p. re2
[DOI: 10.1126/scisignal.3105re2]

REVIEWS

What Is the Function of the Dendritic Cell Side of the Immunological Synapse?

José Luis Rodríguez-Fernández*, Lorena Riol-Blanco{dagger}, and Cristina Delgado-Martín{dagger}

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, C/ Ramiro de Maeztu, 9, 28040 Madrid, Spain.

{dagger} These authors contributed equally to this work.

Gloss: The immune response requires the formation of a specialized interface called the immunological synapse (IS), which is formed between a mature dendritic cell (DC) and a CD4+ T cell in the lymph node. The IS consists of organized motifs formed by cell-surface and cytoplasmic molecules at both the DC side and the T cell side of the IS, herein called IS-DC and IS-T, respectively. Most studies of the IS have focused on the IS-T. In this Review, which contains two figures, one table, and 76 citations, we discuss findings that show that the IS-DC also contributes to the regulation of functions that could be important for the immune response.

* Corresponding author. E-mail, rodrifer{at}cib.csic.es

Citation: J. L. Rodríguez-Fernández, L. Riol-Blanco, C. Delgado-Martín, What Is the Function of the Dendritic Cell Side of the Immunological Synapse? Sci. Signal. 3, re2 (2010).

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