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Sci. Signal., 12 October 2010
Vol. 3, Issue 143, p. re7
[DOI: 10.1126/scisignal.3143re7]

REVIEWS

G Protein–Coupled Receptors in Child Development, Growth, and Maturation

Ana Claudia Latronico1 and Ze’ev Hochberg2*

1 Developmental Endocrinology Unit, Hormone and Molecular Genetics Laboratory (LIM/42), Hospital das Clinicas, Sao Paulo University Medical School, São Paulo 05403-900, Brazil.
2 Meyer Children’s Hospital, Rambam Medical Center, Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, P.O. Box 9602, Haifa 31096, Israel.

Gloss: Naturally occurring mutations of G protein–coupled receptors (GPCRs) are associated with several congenital and sporadic disorders that affect the development and maturation of children and adolescents. In this Review, which contains 58 references and 2 tables, we discuss the effects of various mutant GPCRs on child health.

* Corresponding author. E-mail, Z-hochberg{at}rambam.health.gov.il

Citation: A. C. Latronico, Z. Hochberg, G Protein–Coupled Receptors in Child Development, Growth, and Maturation. Sci. Signal. 3, re7 (2010).

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