Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 12 October 2010
Vol. 3, Issue 143, p. re7
[DOI: 10.1126/scisignal.3143re7]


G Protein–Coupled Receptors in Child Development, Growth, and Maturation

Ana Claudia Latronico1 and Ze’ev Hochberg2*

1 Developmental Endocrinology Unit, Hormone and Molecular Genetics Laboratory (LIM/42), Hospital das Clinicas, Sao Paulo University Medical School, São Paulo 05403-900, Brazil.
2 Meyer Children’s Hospital, Rambam Medical Center, Rappaport Faculty of Medicine and Research Institute, Technion–Israel Institute of Technology, P.O. Box 9602, Haifa 31096, Israel.

Gloss: Naturally occurring mutations of G protein–coupled receptors (GPCRs) are associated with several congenital and sporadic disorders that affect the development and maturation of children and adolescents. In this Review, which contains 58 references and 2 tables, we discuss the effects of various mutant GPCRs on child health.

* Corresponding author. E-mail, Z-hochberg{at}

Citation: A. C. Latronico, Z. Hochberg, G Protein–Coupled Receptors in Child Development, Growth, and Maturation. Sci. Signal. 3, re7 (2010).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882