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Sci. Signal., 26 October 2010
Vol. 3, Issue 145, p. re8
[DOI: 10.1126/scisignal.3145re8]

REVIEWS

Apoptosis, Stem Cells, and Tissue Regeneration

Andreas Bergmann1* and Hermann Steller2*

1 Department of Biochemistry and Molecular Biology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
2 Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Gloss: Tissue regeneration after wounding or amputation generally requires cell proliferation. Work in several model organisms, including Drosophila, Hydra, Xenopus, and mouse, revealed a surprising function for caspases in cell proliferation after tissue damage, in addition to their known role in a form of cell death called apoptosis. In apoptotic cells, caspases can stimulate the production of secreted cytokines, such as Wnt, bone morphogenetic protein (BMP), transforming growth factor–β (TGF-β), Hedgehog family members, and prostaglandins, which in turn induce proliferation of neighboring cells, thus promoting tissue regeneration and homeostasis. These pathways can also contribute to tumorigenesis. This Review summarizes findings on this phenomenon, termed "apoptosis-induced compensatory proliferation," and contains three figures and 110 references.

* Corresponding authors. E-mail: abergman{at}mdanderson.org (A.B.); steller{at}rockefeller.edu (H.S.)

Citation: A. Bergmann, H. Steller, Apoptosis, Stem Cells, and Tissue Regeneration. Sci. Signal. 3, re8 (2010).


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