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Sci. Signal., 26 October 2010
Vol. 3, Issue 145, p. re8
[DOI: 10.1126/scisignal.3145re8]


Apoptosis, Stem Cells, and Tissue Regeneration

Andreas Bergmann1* and Hermann Steller2*

1 Department of Biochemistry and Molecular Biology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
2 Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Gloss: Tissue regeneration after wounding or amputation generally requires cell proliferation. Work in several model organisms, including Drosophila, Hydra, Xenopus, and mouse, revealed a surprising function for caspases in cell proliferation after tissue damage, in addition to their known role in a form of cell death called apoptosis. In apoptotic cells, caspases can stimulate the production of secreted cytokines, such as Wnt, bone morphogenetic protein (BMP), transforming growth factor–β (TGF-β), Hedgehog family members, and prostaglandins, which in turn induce proliferation of neighboring cells, thus promoting tissue regeneration and homeostasis. These pathways can also contribute to tumorigenesis. This Review summarizes findings on this phenomenon, termed "apoptosis-induced compensatory proliferation," and contains three figures and 110 references.

* Corresponding authors. E-mail: abergman{at} (A.B.); steller{at} (H.S.)

Citation: A. Bergmann, H. Steller, Apoptosis, Stem Cells, and Tissue Regeneration. Sci. Signal. 3, re8 (2010).

Gene-expression analysis of hair cell regeneration in the zebrafish lateral line.
L. Jiang, A. Romero-Carvajal, J. S. Haug, C. W. Seidel, and T. Piotrowski (2014)
PNAS 111, E1383-E1392
   Abstract »    Full Text »    PDF »
Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway.
A. Perez-Garijo, Y. Fuchs, and H. Steller (2013)
eLife Sci 2, e01004
   Abstract »    Full Text »    PDF »
Sept4/ARTS Regulates Stem Cell Apoptosis and Skin Regeneration.
Y. Fuchs, S. Brown, T. Gorenc, J. Rodriguez, E. Fuchs, and H. Steller (2013)
Science 341, 286-289
   Abstract »    Full Text »    PDF »
Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling.
T. G. Bird, W.-Y. Lu, L. Boulter, S. Gordon-Keylock, R. A. Ridgway, M. J. Williams, J. Taube, J. A. Thomas, D. Wojtacha, A. Gambardella, et al. (2013)
PNAS 110, 6542-6547
   Abstract »    Full Text »    PDF »
Mechanisms of cell competition: Themes and variations.
R. Levayer and E. Moreno (2013)
J. Cell Biol. 200, 689-698
   Abstract »    Full Text »    PDF »
Beyond the cell: The cell biology of regeneration.
R. S. King and P. A. Newmark (2012)
J. Cell Biol. 196, 553-562
   Abstract »    Full Text »    PDF »
Interleukin-11 Links Oxidative Stress and Compensatory Proliferation.
T. Nishina, S. Komazawa-Sakon, S. Yanaka, X. Piao, D.-M. Zheng, J.-H. Piao, Y. Kojima, S. Yamashina, E. Sano, T. Putoczki, et al. (2012)
Science Signaling 5, ra5
   Abstract »    Full Text »    PDF »
Identification and Characterization of Genes Required for Compensatory Growth in Drosophila.
A. R. Gerhold, D. J. Richter, A. S. Yu, and I. K. Hariharan (2011)
Genetics 189, 1309-1326
   Abstract »    Full Text »    PDF »
Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila.
Y.-i. Nakajima, E. Kuranaga, K. Sugimura, A. Miyawaki, and M. Miura (2011)
Mol. Cell. Biol. 31, 2499-2512
   Abstract »    Full Text »    PDF »
The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development.
A. E. Anderson, U. C. Karandikar, K. L. Pepple, Z. Chen, A. Bergmann, and G. Mardon (2011)
Development 138, 1957-1966
   Abstract »    Full Text »    PDF »

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