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Sci. Signal., 26 October 2010
Vol. 3, Issue 145, p. re8
Apoptosis, Stem Cells, and Tissue Regeneration
Andreas Bergmann1* and
1 Department of Biochemistry and Molecular Biology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. 2 Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
Gloss: Tissue regeneration after wounding or amputation generally requires cell proliferation. Work in several model organisms, including Drosophila, Hydra, Xenopus, and mouse, revealed a surprising function for caspases in cell proliferation after tissue damage, in addition to their known role in a form of cell death called apoptosis. In apoptotic cells, caspases can stimulate the production of secreted cytokines, such as Wnt, bone morphogenetic protein (BMP), transforming growth factor–β (TGF-β), Hedgehog family members, and prostaglandins, which in turn induce proliferation of neighboring cells, thus promoting tissue regeneration and homeostasis. These pathways can also contribute to tumorigenesis. This Review summarizes findings on this phenomenon, termed "apoptosis-induced compensatory proliferation," and contains three figures and 110 references.
Wei Wong (2 February 2010) Sci. Signal.3 (107), ec37.
[DOI: 10.1126/scisignal.3107ec37] |Abstract »
Alma Zernecke, Kiril Bidzhekov, Heidi Noels, Erdenechimeg Shagdarsuren, Lin Gan, Bernd Denecke, Mihail Hristov, Thomas Köppel, Maliheh Nazari Jahantigh, Esther Lutgens, Shusheng Wang, Eric N. Olson, Andreas Schober, and Christian Weber (8 December 2009) Sci. Signal.2 (100), ra81.
[DOI: 10.1126/scisignal.2000610] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Colin Adrain and Seamus J. Martin (6 October 2009) Sci. Signal.2 (91), pe62.
[DOI: 10.1126/scisignal.291pe62] |Abstract »|Full Text »|PDF »
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Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway.