Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. Signal., 30 August 2011
Vol. 4, Issue 188, p. re1
[DOI: 10.1126/scisignal.2001958]

REVIEWS

Inositol Pyrophosphates as Mammalian Cell Signals

Anutosh Chakraborty1, Seyun Kim1, and Solomon H. Snyder1,2,3*

1 The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2 Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Gloss: The inositol pyrophosphates are biological messenger molecules with diverse functions in organisms ranging from slime molds to mammals. Although the existence of inositol pyrophosphates was demonstrated in the early 1990s, substantial progress in understanding their functions in mammalian signaling awaited the identification and cloning of their biosynthetic enzymes and the recent generation of relevant knockout mice. Inositol pyrophosphates have been linked to cellular processes as diverse as vesicular trafficking, telomere length maintenance, apoptosis, and insulin secretion. Phenotypic alterations of mice with targeted deletion of key biosynthetic enzymes have revealed roles for these enzymes and their products in carbohydrate and lipid metabolism, protein synthesis, cancer, and innate immunity. Although yeast and other primitive organisms have provided valuable insights, this review, in the interest of brevity, focuses primarily on mammalian systems.

* Corresponding author: E-mail, ssnyder{at}jhmi.edu

Citation: A. Chakraborty, S. Kim, S. H. Snyder, Inositol Pyrophosphates as Mammalian Cell Signals. Sci. Signal. 4, re1 (2011).

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate.
Y. Xu, H. Li, B. Bajrami, H. Kwak, S. Cao, P. Liu, J. Zhou, Y. Zhou, H. Zhu, K. Ye, et al. (2013)
PNAS 110, 7726-7731
   Abstract »    Full Text »    PDF »
New Horizons in Cellular Regulation by Inositol Polyphosphates: Insights from the Pancreatic {beta}-Cell.
C. J. Barker and P.-O. Berggren (2013)
Pharmacol. Rev. 65, 641-669
   Abstract »    Full Text »    PDF »
Inositol Pyrophosphate Synthesis by Inositol Hexakisphosphate Kinase 1 Is Required for Homologous Recombination Repair.
R. S. Jadav, M. V. L. Chanduri, S. Sengupta, and R. Bhandari (2013)
J. Biol. Chem. 288, 3312-3321
   Abstract »    Full Text »    PDF »
Pyro-Technic Control of Metabolism.
R. F. Irvine and R. M. Denton (2011)
Science 334, 770-771
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882