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Sci. Signal., 18 December 2012
Vol. 5, Issue 255, p. re7
[DOI: 10.1126/scisignal.2003273]

REVIEWS

Extracellular Phosphorylation and Phosphorylated Proteins: Not Just Curiosities But Physiologically Important

Garif Yalak and Viola Vogel*

Department of Health Sciences and Technology, ETH Zurich, Wolfgang Pauli Strasse 10, HCI F443, CH-8093 Zurich, Switzerland.

Gloss: With 3 figures, 1 table, and 221 references plus 2 supplementary figures and 1 supplementary table, this Review describes the evidence supporting physiological and pathological functions of phosphorylated extracellular proteins. In addition, evidence for extracellular phosphorylation in various contexts and tissues is also presented. To facilitate the study of the extracellular phosphoproteome, annotation of the phosphorylated proteins found in proteomic databases is supplied.

* Corresponding author. E-mail: viola.vogel{at}hest.ethz.ch

Citation: G. Yalak, V. Vogel, Extracellular Phosphorylation and Phosphorylated Proteins: Not Just Curiosities But Physiologically Important. Sci. Signal. 5, re7 (2012).



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