Nonredundant Functions for Ras GTPase-Activating Proteins in Tissue Homeostasis

Philip D. King^*, Beth A. Lubeck, and Philip E. Lapinski

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA

Gloss: Many cell surface receptors trigger activation of the small guanosine triphosphate–binding protein Ras, conveying signals for cell proliferation, survival, and differentiation. However, excessive Ras activation results in uncontrolled tissue growth and susceptibility to diseases, such as cancer. Ras guanosine triphophatase (GTPase)–activating proteins (RasGAPs) inactivate Ras to maintain normal signaling activity. This Review, which has 2 figures, 2 tables, and 147 references, discusses the role of individual RasGAP family members in normal tissue and in disease.

* Corresponding author. E-mail: kingp{at}umich.edu

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