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Sci. Signal., 23 April 2013
Vol. 6, Issue 272, p. re2
[DOI: 10.1126/scisignal.2003832]


Signaling Mechanisms in Mammalian Myoblast Fusion

Sajedah M. Hindi, Marjan M. Tajrishi, and Ashok Kumar*

Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.

Gloss: Skeletal muscles are formed by the fusion of multiple myoblasts during development. Myoblast fusion is also essential for the growth and repair of injured myofibers. Recent investigations have shown that the process of myoblast fusion involves the activation of several cell signaling pathways, including those mediated by nuclear factor {kappa}B, mitogen-activated protein kinases, Wnt, calcineurin–nuclear factor of activated T cells c2, transforming growth factor–β–Smad4, and the Rho guanosine triphosphatases. In this Review, which contains 2 figures and 84 references, we summarize the mechanisms by which the activation of these signaling pathways stimulates myoblast fusion.

* Corresponding author. E-mail: ashok.kumar{at}

Citation: S. M. Hindi, M. M. Tajrishi, A. Kumar, Signaling Mechanisms in Mammalian Myoblast Fusion. Sci. Signal. 6, re2 (2013).

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