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Sci. Signal., 20 August 2013
Vol. 6, Issue 289, p. re5
[DOI: 10.1126/scisignal.2004099]

REVIEWS

Potential Pathological and Functional Links Between Long Noncoding RNAs and Hematopoiesis

Bo-Wei Han and Yue-Qin Chen*

Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Science, Sun Yat-sen University, Guangzhou 510275, P. R. China.

Gloss: Long noncoding RNAs (lncRNAs) are a class of transcripts that do not encode proteins and are greater than 200 nucleotides in length. Accumulating evidence suggests that lncRNAs are involved in normal development and in disease progression, including normal and malignant hematopoiesis. In this Review with 2 figures, 2 tables, and 87 references, we describe the progress in understanding the roles of lncRNAs in hematopoiesis and blood cell signaling. We also discuss the current and potential future application of lncRNAs as diagnostic and prognostic indicators in malignant hematopoiesis, as well as the prospect that lncRNAs may serve as therapeutic targets in leukemia and other blood diseases.

* Corresponding author. E-mail: lsscyq{at}mail.sysu.edu.cn

Citation: B.-W. Han, Y.-Q. Chen, Potential Pathological and Functional Links Between Long Noncoding RNAs and Hematopoiesis. Sci. Signal. 6, re5 (2013).



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