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Sci. Signal., 8 October 2013
Vol. 6, Issue 296, p. re7
Hippo Gains Weight: Added Insights and Complexity to Pathway Control
Leonie Enderle1,2 and
1 Biozentrum, University of Basel, 4056 Basel, Switzerland. 2 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Gloss: During development, cell growth must be tightly regulated to allow a tissue or organ to reach its proper size. The Hippo pathway is a major negative regulator of tissue growth and is also involved in tumor suppression. In this Review, with three figures and 114 references, we focus on this pathway in the fruit fly Drosophila melanogaster, a model organism in which many of the key components of the pathway and its regulatory inputs have been identified. In Drosophila, the Hippo pathway consists of a central kinase cascade formed by Hippo, Salvador, Warts, and Mats, and this cascade regulates the subcellular distribution and transcriptional activity of Yorkie. Insights into upstream regulation of the Hippo core pathway have identified factors at the apical membrane of the cell and at cell-cell junctions, such as cell adhesion molecules and scaffolding proteins, as well as regulators of apical-basal polarity. Excitingly, the cytoskeleton and extracellular tension cues are also important regulators of the Hippo pathway.
Amber L. Couzens, James D. R. Knight, Michelle J. Kean, Guoci Teo, Alexander Weiss, Wade H. Dunham, Zhen-Yuan Lin, Richard D. Bagshaw, Frank Sicheri, Tony Pawson, Jeffrey L. Wrana, Hyungwon Choi, and Anne-Claude Gingras (19 November 2013) Sci. Signal.6 (302), rs15.
[DOI: 10.1126/scisignal.2004712] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
L. Bryan Ray (12 November 2013) Sci. Signal.6 (301), ec274.
[DOI: 10.1126/scisignal.2004893] |Abstract »
Annalisa M. VanHook (15 October 2013) Sci. Signal.6 (297), ec249.
[DOI: 10.1126/scisignal.2004811] |Abstract »
Emad Heidary Arash and Liliana Attisano (14 May 2013) Sci. Signal.6 (275), pe18.
[DOI: 10.1126/scisignal.2004259] |Abstract »|Full Text »|PDF »
Jane I. Lin, Carole L. C. Poon, and Kieran F. Harvey (22 January 2013) Sci. Signal.6 (259), pe4.
[DOI: 10.1126/scisignal.2003813] |Abstract »|Full Text »|PDF »