Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Signal., 30 September 2008
[DOI: 10.1126/scisignal.1160583]

Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

Ursula Schenk,1 Astrid M. Westendorf,2 Enrico Radaelli,3 Anna Casati,1,4 Micol Ferro,1 Marta Fumagalli,5 Claudia Verderio,6 Jan Buer,2 Eugenio Scanziani,3 Fabio Grassi1*

11Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland.

2Institute of Medical Microbiology, University Hospital Essen, 45122 Essen, Germany.

3Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, 20100 Milan, Italy.

4Department of Biology and Genetics for Medical Sciences, University of Milan, 20100 Milan, Italy.

5Department of Pharmacological Sciences, University of Milan, 20100 Milan, Italy.

6Department of Medical Pharmacology, CNR Institute of Neuroscience, University of Milan, 20100 Milan, Italy.

This PDF file includes:

  • Fig. S1. Decreased CRAC inactivation and unaltered mitochondrial membrane potential in crt–/– T cells.
  • Fig. S2. Analysis of ATP release from activated T cells.
  • Fig. S3. Reduced Ca2+ entry, ATP synthesis, and ATP release in Tregs.
  • Fig. S4. Analyses of purinergic receptor expression and function in T cells.
  • Fig. S5. Influence of oATP and pannexin hemichannel inhibitors on productive T cell activation.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 575 KB

*To whom correspondence should be addressed. E-mail: fabio.grassi{at}

Citation: U. Schenk, A. M. Westendorf, E. Radaelli, A. Casati, M. Ferro, M. Fumagalli, C. Verderio, J. Buer, E. Scanziani, F. Grassi, Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels. Sci. Signal. 1, ra6 (2008).

© 2008 American Association for the Advancement of Science

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882