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Sci. Signal., 26 February 2008
Vol. 1, Issue 8, p. pe11
[DOI: 10.1126/stke.18pe11]

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A Cytoskeletal Platform for Local Translation in Axons

Francisca P. G. Van Horck and Christine E. Holt*

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.

Abstract: Recent data indicate that local translation in growth cones is critical for axon guidance. Evidence from the Drosophila midline axon guidance system suggests that the F-actin-microtubule cross-linker Short stop (Shot) might link the translation machinery to the cytoskeleton in the growth cone. The identification of a complex of translation factors attached to the actin and microtubule networks points to a mechanism by which cytoskeletal dynamics regulate translation in axons and vice versa.

*Corresponding author. E-mail: ceh{at}mole.bio.cam.ac.uk

Citation: F. P. G. Van Horck, C. E. Holt, A Cytoskeletal Platform for Local Translation in Axons. Sci. Signal. 1, pe11 (2008).

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