Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis

Caterina Nardella,¹ Arkaitz Carracedo,¹* Andrea Alimonti,¹* Robin M. Hobbs,¹ John G. Clohessy,¹ Zhenbang Chen,¹ Ainara Egia,1 Alessandro Fornari,^2,3 Michelangelo Fiorentino,² Massimo Loda,^2,4 Sara C. Kozma,⁵ George Thomas,⁵ Carlos Cordon-Cardo,⁶ Pier Paolo Pandolfi^1†

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• Materials and Methods
• Fig. S1. α6 integrin is predominantly expressed by cytokeratin 5 (CK5)–positive basal prostatic epithelial cells.
• Fig. S2. Residual PIN-affected glands in Pten^pc-/-;mTor^pc-/- mice arise from Pten- recombined cells that have escaped mTor recombination.
• Fig. S3. Deletion of mTor in MEFs.

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¹Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. ²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. ³Department of Biomedical Sciences and Human Oncology, Molinette Hospital, University of Turin, 10126 Turin, Italy. ⁴Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ⁵Department of Genome Science, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA. ⁶Department of Pathology, Columbia University, New York, NY 10032, USA.
*These authors contributed equally to this work.
†To whom correspondence should be addressed. E-mail, vppandolf{at}bidmc.harvard.edua

Citation: C. Nardella, A.Carracedo, A. Alimonti, R. M. Hobbs, J. G. Clohessy, Z. Chen, A. Egia, A. Fornari, M. Fiorentino, M. Loda, S. C. Kozma, G. Thomas, C. Cordon-Cardo, P. P. Pandolfi, Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis. Sci. Signal. 2, ra2 (2009).

© 2009 American Association for the Advancement of Science