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Sci. Signal., 27 January 2009
[DOI: 10.1126/scisignal.2000189]

Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis

Caterina Nardella,1 Arkaitz Carracedo,1* Andrea Alimonti,1* Robin M. Hobbs,1 John G. Clohessy,1 Zhenbang Chen,1 Ainara Egia,1 Alessandro Fornari,2,3 Michelangelo Fiorentino,2 Massimo Loda,2,4 Sara C. Kozma,5 George Thomas,5 Carlos Cordon-Cardo,6 Pier Paolo Pandolfi1†

This PDF file includes:

  • Materials and Methods
  • Fig. S1. α6 integrin is predominantly expressed by cytokeratin 5 (CK5)–positive basal prostatic epithelial cells.
  • Fig. S2. Residual PIN-affected glands in Ptenpc-/-;mTorpc-/- mice arise from Pten- recombined cells that have escaped mTor recombination.
  • Fig. S3. Deletion of mTor in MEFs.

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1Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. 2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. 3Department of Biomedical Sciences and Human Oncology, Molinette Hospital, University of Turin, 10126 Turin, Italy. 4Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. 5Department of Genome Science, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45237, USA. 6Department of Pathology, Columbia University, New York, NY 10032, USA.
*These authors contributed equally to this work.
†To whom correspondence should be addressed. E-mail, vppandolf{at}bidmc.harvard.edua

Citation: C. Nardella, A.Carracedo, A. Alimonti, R. M. Hobbs, J. G. Clohessy, Z. Chen, A. Egia, A. Fornari, M. Fiorentino, M. Loda, S. C. Kozma, G. Thomas, C. Cordon-Cardo, P. P. Pandolfi, Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis. Sci. Signal. 2, ra2 (2009).

© 2009 American Association for the Advancement of Science

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