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Sci. Signal., 19 May 2009
[DOI: 10.1126/scisignal.2000278]

Supplementary Materials for:

TRPM2 Functions as a Lysosomal Ca2+-Release Channel in β Cells

Ingo Lange, Shinichiro Yamamoto, Santiago Partida-Sanchez, Yasuo Mori, Andrea Fleig, Reinhold Penner*

*To whom correspondence should be addressed. E-mail: rpenner{at}hawaii.edu

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Thapsigargin prevents Ca2+ release induced by extracellular ADPR.
  • Fig. S2. Extracellular cADPR and NAD+ evoke Ca2+ signals in INS-1 β cells.
  • Fig. S3. 8-Br-ADPR application inhibits Ca2+ release by cADPR.
  • Fig. S4. Statistical analysis of Ca2+ signals induced by external or internal ADPR in β cells.
  • Table S1. Statistical analysis of agonist-induced Ca2+ signals in TRPM2 HEK and β cells.

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Technical Details

Format: Adobe Acrobat PDF

Size: 747 KB


Citation: I. Lange, S. Yamamoto, S. Partida-Sanchez, Y. Mori, A. Fleig, R. Penner, TRPM2 functions as a lysosomal Ca2+-release channel in β cells. Sci. Signal. 2, ra23 (2009).

© 2009 American Association for the Advancement of Science


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