TRPM2 Functions as a Lysosomal Ca²⁺-Release Channel in β Cells

Ingo Lange, Shinichiro Yamamoto, Santiago Partida-Sanchez, Yasuo Mori, Andrea Fleig, Reinhold Penner*

*To whom correspondence should be addressed. E-mail: rpenner{at}hawaii.edu

This PDF file includes:

• Materials and Methods
• Fig. S1. Thapsigargin prevents Ca²⁺ release induced by extracellular ADPR.
• Fig. S2. Extracellular cADPR and NAD⁺ evoke Ca²⁺ signals in INS-1 β cells.
• Fig. S3. 8-Br-ADPR application inhibits Ca²⁺ release by cADPR.
• Fig. S4. Statistical analysis of Ca²⁺ signals induced by external or internal ADPR in β cells.
• Table S1. Statistical analysis of agonist-induced Ca²⁺ signals in TRPM2 HEK and β cells.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 747 KB

Citation: I. Lange, S. Yamamoto, S. Partida-Sanchez, Y. Mori, A. Fleig, R. Penner, TRPM2 functions as a lysosomal Ca²⁺-release channel in β cells. Sci. Signal. 2, ra23 (2009).

© 2009 American Association for the Advancement of Science