Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 23 June 2009
[DOI: 10.1126/scisignal.2000046]

Supplementary Materials for:

PKC-θ Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation

Thomas Gruber, Natascha Hermann-Kleiter, Reinhard Hinterleitner, Friedrich Fresser, Rainer Schneider, Günther Gastl, Josef M. Penninger, Gottfried Baier*

*To whom correspondence should be addressed. E-mail: gottfried.baier{at}i-med.ac.at

This PDF file includes:

  • Fig. S1. PKCθ-deficient T cells exhibit hyporesponsiveness.
  • Fig. S2. The PKC-θ–dependent recall response is restored to WT levels in DKO T cells.
  • Fig. S3. PKC-θ phosphorylates the TKB domain of Cbl-b in vitro.
  • Table S1. Effects of single or double deficiencies in cblb and PKCθ on cellularity.
  • Table S2. Relative abundance of CD25, CD44, and CD69 on CD3+ T cells by genotype.
  • Table S3. Specific interactions between PKC-θ and Cbl-b in the GAL4 yeast two-hybrid system.
  • References

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 455 KB


Citation: T. Gruber, N. Hermann-Kleiter, R. Hinterleitner, F. Fresser, R. Schneider, G. Gastl, J. M. Penninger, G. Baier, PKC-θ modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Sci. Signal. 2, ra30 (2009).

© 2009 American Association for the Advancement of Science


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882