Control of Neuronal Growth Cone Navigation by Asymmetric Inositol 1,4,5-Trisphosphate Signals

Hiroki Akiyama, Toru Matsu-ura, Katsuhiko Mikoshiba, Hiroyuki Kamiguchi*

*To whom correspondence should be addressed. E-mail: kamiguchi{at}brain.riken.jp

This PDF file includes:

• Materials and Methods
• Fig. S1. IP₃R distribution in chick DRG growth cones.
• Fig. S2. NGF gradients elicit asymmetric IP3 signals in growth cones grown on laminin.
• Fig. S3. Global Ca²⁺ signals in the growth cone triggered by photolysis of caged IP3.
• Fig. S4. Global Ca²⁺ signals triggered by PLC activation in the growth cone.
• Fig. S5. Time course of changes in the spatial distribution of reagents ejected from a micropipette.
• References

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Citation: H. Akiyama, T. Matsu-ura, K. Mikoshiba, H. Kamiguchi, Control of neuronal growth cone navigation by asymmetric inositol 1,4,5-trisphosphate signals. Sci. Signal. 2, ra34 (2009).

© 2009 American Association for the Advancement of Science