Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA–Induced Dyskinesia

Emanuela Santini, Myriam Heiman, Paul Greengard, Emmanuel Valjent, Gilberto Fisone*

*To whom correspondence should be addressed. E-mail: gilberto.fisone{at}ki.se

This PDF file includes:

• Fig. S1. Rapamycin does not affect L-DOPA–induced phosphorylation of GluR1 and ERK2.
• Fig. S2. Rapamycin does not affect L-DOPA–induced phosphorylation of Lys¹⁴-acetylated histone H3.
• Fig. S3. Evaluation of the degree of DA denervation after striatal 6-OHDA injection.
• Table S1. Effect of 6-OHDA and L-DOPA on selected proteins involved in mTOR signaling.

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Citation: E. Santini, M. Heiman, P. Greengard, E. Valjent, G. Fisone, Inhibition of mTOR signaling in Parkinson’s disease prevents L-DOPA–induced dyskinesia. Sci. Signal. 2, ra36 (2009).

© 2009 American Association for the Advancement of Science