Intracellular Delivery of a Cell-Penetrating SOCS1 that Targets IFN-γ Signaling

Antonio DiGiandomenico, Lukasz S. Wylezinski, Jacek Hawiger*

*To whom correspondence should be addressed. E-mail: jacek.hawiger{at}vanderbilt.edu

This PDF file includes:

• Fig. S1. Quantification of intracellular CP-SOCS1.
• Fig. S2. Transfection of HEK 293F cells with plasmids encoding CP-SOCS1 or non–CP-SOCS1 results in a similar inhibition of STAT1 phosphorylation.
• Fig. S3. The action of intracellular CP-SOCS1 is short-lived and reversible.
• Fig. S4. Transfection of HEK 293T cells with plasmids encoding non–CP-SOCS1 or CP-SOCS1 inhibits IFN-γ–induced production of chemokines.

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Citation: A. DiGiandomenico, L. S. Wylezinski, J. Hawiger, Intracellular delivery of a cell-penetrating SOCS1 that targets IFN-γ signaling. Sci. Signal. 2, ra37 (2009).

© 2009 American Association for the Advancement of Science