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Sci. Signal., 15 September 2009
[DOI: 10.1126/scisignal.2000304]

Supplementary Materials for:

Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis

Helen P. Makarenkova,* Matthew P. Hoffman, Andrew Beenken, Anna V. Eliseenkova, Robyn Meech, Cindy Tsau, Vaishali N. Patel, Richard A. Lang, Moosa Mohammadi

*To whom correspondence should be addressed. E-mail: hmakarenk{at}scripps.edu

This PDF file includes:

  • Fig. S1. Relationship between the distance from the FGF and the effect on the bud.
  • Fig. S2. Biological responses of isolated SMG epithelial explants to FGF10, FGF10-HS mutants, or FGF7 in an ECM-diffusion assay with exogenous heparin, heparitinase, or ChABC added to the media.
  • Table S1. Summary of the effects of FGF7, FGF10, and FGF10-HS mutants on branching morphogenesis of LG and SMG epithelium.
  • Table S2. Genome-wide microarray analysis of isolated SMG epithelial explants treated with FGF10, FGF7, FGF10R187V, or FGF10R193K.
  • Table S3. Genes increased or decreased in expression in FGF10-treated LG explants relative to FGF7- or FGF10R187V-treated explants.

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Technical Details

Format: Adobe Acrobat PDF

Size: 3.1 MB


Citation: H. P. Makarenkova, M. P. Hoffman, A. Beenken, A. V. Eliseenkova, R. Meech, C. Tsau, V. N. Patel, R. A. Lang, M. Mohammadi, Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis. Sci. Signal. 2, ra55 (2009).

© 2009 American Association for the Advancement of Science


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