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Sci. STKE, 7 January 2003
[DOI: 10.1126/stke.2003.164.pe1]

Table 1. Structures from J. H. Hurley, GAF domains: Cyclic nucleotides come full circle

Table 1. Structures from J. H. Hurley, GAF domains: Cyclic nucleotides come full circle.

Protein or Domain Entrez-linked PDB accession number Reference
Regulatory segment of mouse 3',5' cyclic nucleotide phosphodiesterase 2a, containing the Gaf A and Gaf B domains 1MC0 (1)
Rat type II adenylyl cyclase C2 domain: Forskolin complex 1AB8 (2)
Complex of G{alpha}s with the catalytic domains of mammalian adenylyl cyclase: Complex with {beta}-L-2',3'-dideoxyATP and Mg 1CJU (3)
Complex of G{alpha}s with the catalytic domains of mammalian adenylyl cyclase: Complex with {beta}-L-2',3'-dideoxyATP, Mn, and Mg 1CJT (3)
Complex of G{alpha}s with the catalytic domains of mammalian adenylyl cyclase 1AZS (4)
Complex of G{alpha}s with the catalytic domains of mammalian adenylyl cyclase: Complex with 2'-deoxy-adenosine 3'-monophosphate, pyrophosphate, and Mg 1CS4 (4, 5)
Complex of G{alpha}s with the catalytic domains of mammalian adenylyl cyclase: Complex with {beta}-L-2',3'-dideoxyATP, Mg, and Zn 1CJV (3)
Complex of G{alpha}s with the catalytic domains of mammalian adenylyl cyclase: Complex with adenosine 5'-(alpha thio)-triphosphate (Rp), Mg, and Mn 1CJK (3)
Catalytic domain of human phosphodiesterase 4b2b 1F0J (6)
Regulatory subunit of cAMP-dependent protein kinase 1RGS (6)
Structure of the GAF domain 1F5M (8)
2.1 Angstrom Structure of CAP-cAMP 1G6N (9)

References

  1. S. E. Martinez, A. Y. Wu, N. A. Glavas, X. -B. Tang, S. Turley, W. Hol., J. A. Beavo, The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proc. Natl. Acad. Sci. U.S.A. 99, 13260-13265 (2002). [Abstract/Full Text]
  2. G. Zhang, Y. Liu, A. E. Ruoho, J. H.Hurley, Structure of the adenylyl cyclase catalytic core. Nature 386, 247-253 (1997). [Abstract]
  3. J. J. Tesmer, R. K. Sunahara, R. A. Johnson, G. Gosselin, A. G. Gilman, S. R. Sprang, Two-metal-ion catalysis in adenylyl cyclase. Science 285, 756-760 (1999). [Abstract/Full Text]
  4. J. J. Tesmer, R. K. Sunahara, A. G. Gilman, S. R. Sprang, Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gs{alpha}-GTPγS. Science 278, 1907-1916 (1997). [Abstract/Full Text]
  5. J. J.Tesmer, C. W. Dessauer, R. K. Sunahara, L. D. Murray, R. A. Johnson, A. G. Gilman, S. R. Sprang, Molecular basis for P-site inhibition of adenylyl cyclase. Biochemistry 39, 14464-14471 (2000). [Abstract]
  6. R. X. Xu, A. M. Hassell, D. Vanderwall, M. H. Lambert, W. D. Holmes, M. A. Luther, W. J. Rocque, M. V. Milburn, Y. Zhao, H. Ke, R. T. Nolte, Atomic structure of PDE4: Insights into phosphodiesterase mechanism and specificity. Science 288, 1822-1825 (2000). [Abstract/Full Text]
  7. Y. Su, W. R. G. Dostmann, F. W. Herberg, K. Durick, N.-h. Xoung, L. Ten Eyck, S. S. Taylor, K. I. Varughese. Regulatory subunit of protein kinase A- Structure of a deletion mutant with cAMP binding domains. Science 269, 807-813 (1995). [Abstract]
  8. Y. S. Ho., L. M. Burden, J. H. Hurley, Structure of the GAF domain, a ubiquitious signaling motif and a new class of cyclic GMP receptor. EMBO J. 19, 5288-5299 (2000). [Abstract/Full Text]
  9. J. M. Passner, S. C. Schultz, T. A. Steitz, Modeling the cAMP-induced allosteric transition using the crystal structure of CAP-cAMP at 2.1 resolution. J. Mol. Biol. 304, 847-859 (2000). [Abstract]

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    Citation: J. H. Hurley, GAF domains: Cyclic nucleotides come full circle. Sci. STKE 2003, pe1 (2003).

    © 2003 American Association for the Advancement of Science


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