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Sci. STKE, 22 April 2003
[DOI: 10.1126/stke.2003.179.eg6]

A Series on Protein Domains in Signal Transduction

16 December 2003
Lipid-Binding Structures 16 December 03



  • Finding Partners: Emerging Protein Interaction Technologies Applied to Signaling Networks
    Igor Stagljar
    SILAC, TAIS, domain profiling, and mbYTH are new methods for revealing protein partners. [Summary] [Full Text] [PDF]

18 November 2003
Structures in Signaling 18 November 03


  • Organization and Functions of Interacting Domains for Signaling by Protein-Protein Interactions
    Elizabeth Buck and Ravi Iyengar
    Division of labor in protein interaction domains appears to separate binding from actual signal transfer. [Gloss] [Abstract] [Full Text] [PDF]

15 July 2003
Structures in Signaling 15 July 03


  • SH2 and PTB Domains in Tyrosine Kinase Signaling
    Joseph Schlessinger and Mark A. Lemmon
    Motifs that recognize phosphorylated tyrosines are essential regulators of cellular signaling events. [Gloss] [Abstract] [Full Text] [PDF]

  • A Kelch b-Propeller Featuring as a Gb Structural Mimic: Reinventing the Wheel?
    Jan Gettemans, Kris Meerschaert, Joël Vandekerckhove, and Veerle De Corte
    Structural similarity may allow proteins with diverse primary sequences to serve in the G protein heterotrimer. [Summary] [Full Text] [PDF]

Teaching Resources

  • Activation of Ras by Grb2-SOS: Demonstrating an Assembly Role of SH3 Domains
    Ali Zarrinpar, Roby P. Bhattacharyya, Wendell A. Lim, and Nancy R. Gough
    A simple animation showing how SH3 domains participate in mitogen-activated protein kinase signaling. [Summary] [Resource]

22 April 2003
Structures in Signaling 22 April 03


  • Gene Regulation at the RNA Layer: RNA-Binding Proteins in Intercellular Signaling Networks
    Paul Lasko
    How extracellular signals can regulate RNA processing, transport, and translation to control gene expression. [Gloss] [Abstract] [Full Text] [PDF]
  • PDZ Domain Proteins: Plug and Play!
    Claire Nourry, Seth G. N. Grant, and Jean-Paul Borg
    PDZ domains provide the scaffold for functional complexes implicated in health and disease in polar cells. [Gloss] [Abstract] [Full Text] [PDF]
  • The Structure and Function of Proline Recognition Domains
    Ali Zarrinpar, Roby P. Bhattacharyya, and Wendell A. Lim
    Understanding the structural basis of a commonly used motif present in many proteins involved in signal transduction.[Gloss] [Abstract] [Full Text] [PDF] [Structures]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882