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Sci. STKE, 15 February 2005
[DOI: 10.1126/stke.2712005tr5]

Ras-MAPK Pathways
(PowerPoint Slides)

Andrew Chan*

Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.


*Corresponding author. E-mail: andrew.chan{at}


These PowerPoint slides were designed for a lecture covering three kinase-mediated signaling pathways. This lecture is part of the course “Cell Signaling Systems: A Course for Graduate Students.” The focus of the lecture is three major signaling cascades that are implicated in cell proliferation, survival, and stress response. They are, respectively, the mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and Jun N-terminal kinase (JNK) cascades. The aim of this lecture is to review the major players of these intracellular signaling cascades in mammalian cells. In addition, emphasis is placed on understanding the dynamic, rather than linear, nature of signal transduction in determining cellular responses to external stimuli.

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Educational Details

Learning Resource Type: PowerPoint slides

Context: Undergraduate upper division, graduate, professional (degree program)

Intended Users: Teacher, learner

Intended Educational Use: Teach, learn

Discipline: Cell biology, molecular biology

Keywords: signal transduction, MAPK cascade, tumor-associated genes, Ras, B-Raf, FRET

Technical Details

Format: PowerPoint

Size: 7.98 MB

Requirements: Microsoft PowerPoint

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the teaching resource.


Citation: A. Chan, Ras-MAPK Pathways. Sci. STKE 2005, tr5 (2005).

© 2005 American Association for the Advancement of Science

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