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Sci. STKE, 22 March 2005
[DOI: 10.1126/stke.2762005tr10]

Structure of G Protein-Coupled Receptors and G Proteins
(PowerPoint Slides and Movie)

Ravi Iyengar*

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.


*Contact information. E-mail, ravi.iyengar{at}


Slides and a movie are provided for a class covering the structure and function of G protein-coupled receptors (GPCRs) and both are part of the course “Cell Signaling Systems: A Course for Graduate Students.” The slides begin with a discussion of the crystal structure of rhodopsin and G protein and then proceed to describe the molecular mechanisms of receptor activation and the subsequent release of G proteins.

[Access Slides]

The movie is provided with permission from Park et al. [Biochemistry 43, 15643-15656 (2004), copyright 2004 American Chemical Society]. The movie requires the DivX plug-in and shows activation of inactive G protein following interaction with GPCR dimers using space-filling structures for each molecule. The movie may also be accessed from the Biochemistry site ( or here, using the link below.

[Access Movie]

Educational Details

Learning Resource Type: PowerPoint slides and movie

Context: Undergraduate upper division, graduate, professional (degree program)

Intended Users: Teacher, learner

Intended Educational Use: Teach, learn, plan

Discipline: Biochemistry, Molecular Biology, Pharmacology, Structural Biology

Keywords: GPCR, rhodopsin structure, G protein activation, switch II region, Gα, Gβγ

Technical Details Slides

Format: PowerPoint (ppt)

Size: 7.95 MB

Requirements: Microsoft PowerPoint

Technical Details Movie

Format: Movie (avi)

Size: 27.5 MB

Requirements: DivX plug-in, Windows ( or Mac (

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the Teaching Resource.


Citation: R. Iyengar, Structure of G protein-coupled receptors and G proteins. Sci. STKE 2005, tr10 (2005).

© 2005 American Association for the Advancement of Science

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