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Sci. STKE, 6 December 2005
[DOI: 10.1126/stke.3132005tr27]

Regulation of Complexes by Cytoskeletal Elements:
Integrins Serve as Force Transducers Linking Mechanical Stimuli and Biochemical Signals
(PowerPoint Slides and Movie)

Dan P. Felsenfeld*

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.


*Corresponding author. E-mail: dan.felsenfeld{at}


Slides and a movie are provided for a class covering the integrin family members and the downstream signaling pathways they activate and are part of the course “Cell Signaling Systems: A Course for Graduate Students.” The lecture focuses on the capacity of integrins to serve as mechanotransducers, with particular emphasis on signaling mechanisms downstream of integrins.

The movie is the author's work and shows the interaction of NIH 3T3 fibroblasts with beads coated with the integrin-binding domain of fibronectin (FNIII 7-10), which illustrates the ligand-dependent association between integrins and treadmilling actin in the cytosol. Slide 10 is where this movie fits into the slides. Similar results have been published by Felsenfeld et al. [Nature 383, 438-440 (1996)].

[Access Slides] [Access Movie]

Educational Details

Learning Resource Types: PowerPoint slides and movie

Context: Undergraduate upper division, graduate, professional (degree program)

Intended Users: Teacher, learner

Intended Educational Use: Teach, learn, plan

Discipline: Biochemistry, molecular biology, pharmacology, structural biology, cell biology

Keywords: Integrins, extracellular matrix, adhesion receptors, cell motility, mechanotransduction

Technical Details

Format: PowerPoint (ppt)

Size: 33.5 MB

Requirements: Microsoft PowerPoint

Format: QuickTime Movie (mov)

Size: 15.2 MB

Requirements: QuickTime Player

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the Teaching Resource.


Citation: D.P. Felsenfeld, Regulation of complexes by cytoskeletal elements: Integrins as force transducers: a link between mechanical stimuli and biochemical signals. Sci. STKE 2005, tr27 (2005).

© 2005 American Association for the Advancement of Science

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