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Sci. STKE, 3 April 2007
[DOI: 10.1126/stke.3802007tr1]

Molecular Animation of Cell Death Mediated by the Fas Pathway

Drew Berry*

1The Walter and Eliza Hall Institute of Medical Research, 1 G Royal Parade, Parkville, Victoria 3050 Australia

Description

The movie shows the events from activation of the death receptor through degradation of the actin cytoskeleton using molecular representations based on the known crystal structures of the proteins or macromolecular structures involved in the process. The magnification at each stage is provided and represents cellular views at 5,000 and 8,000 and an intracellular or molecular view at 10,000,000 to visualize the proteins and molecular complexes. Readers are referred to the suggested reading list in the full text for the articles used to create the movie.

This movie would be useful in the context of a cell biology course, developmental biology course, or immunology course to illustrate the process of death receptor-mediated apoptosis. In addition, this movie could be used in a biochemistry course or structural biology course to illustrate the formation of macromolecular complexes involved in enzyme activation or signal transduction.

Small Web versions of the movie are available from the links below. Higher resolution (larger file size) versions may be requested from wehi-tv@wehi.edu.au.

[Play Movie] [Click to Download a Zipped Version]

Educational Details

Learning Resource Type: Movie

Context: Undergraduate upper division, graduate, professional (degree program)

Intended Users: Teacher, learner

Intended Educational Use: Teach, learn

Discipline: Biochemistry, cell biology, developmental biology, immunology

Keywords: apoptosis, death receptor, caspase, apoptosome

Technical Details

Format: QuickTime movie (mov file)

Size: 36 MB

Requirements: This movie will play with QuickTime 7 or higher (http://www.apple.com/quicktime).

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the Teaching Resource.

* Corresponding author. E-mail: berry{at}wehi.edu.au

Citation: D. Berry, Molecular animation of cell death mediated by the Fas pathway. Sci. STKE 2007, tr1 (2007).

© 2007 American Association for the Advancement of Science

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882