Focus Issue: Keeping the Immune Response in Check

John F. Foley^1*, Elizabeth M. Adler¹, and Nancy R. Gough²

¹Associate Editor of Science's STKE,
²Editor of Science's STKE, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Summary: When exploring control of a biological system such as the inflammatory response, we often think first of mechanisms that promote activation of the system. But just as important are the signals that that modulate and terminate these processes. Unchecked recruitment and infiltration of leukocytes into tissues and the unrestrained production of pro-inflammatory cytokines and chemokines can lead to tissue damage and even cancer. This issue of Science’s STKE highlights studies that enhance our understanding of how pro-inflammatory signals are switched on, and--equally important--how they are switched off.

*Contact Information. E-mail: jfoley{at}aaas.org

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORS' CHOICE
Immunology
Preventing Runaway Inflammation

Nancy R. Gough (28 June 2011)
Sci. Signal. 4 (179), ec180. [DOI: 10.1126/scisignal.4179ec180]
 |  Abstract »

EDITORIAL GUIDES
Immunology
Focus Issue: External and Internal Regulators of Immune Responses

John F. Foley and Nancy R. Gough (19 January 2010)
Sci. Signal. 3 (105), eg2. [DOI: 10.1126/scisignal.3105eg2]
 |  Abstract »  |  Full Text »  |  PDF »

EDITORS' CHOICE
Immunology
Turning NF-B On and Off

Wei Wong (10 March 2009)
Sci. Signal. 2 (61), ec91. [DOI: 10.1126/scisignal.261ec91]
 |  Abstract »

EDITORS' CHOICE
Immunology
The Timing Is in the Genes

Wei Wong (24 February 2009)
Sci. Signal. 2 (59), ec69. [DOI: 10.1126/scisignal.259ec69]
 |  Abstract »

EDITORS' CHOICE
Immunology
TAMping Down Innate Immune Responses

Nancy R. Gough (18 December 2007)
Sci. STKE 2007 (417), tw458. [DOI: 10.1126/stke.4172007tw458]
 |  Abstract »

EDITORS' CHOICE
Inflammation
Getting Inflamed About a Damaged Extracellular Matrix

Elizabeth M. Adler (26 June 2007)
Sci. STKE 2007 (392), tw227. [DOI: 10.1126/stke.3922007tw227]
 |  Abstract »

EDITORS' CHOICE
Protein Degradation
Nuclear Shut Off of NF-B

Nancy R. Gough (29 May 2007)
Sci. STKE 2007 (388), tw186. [DOI: 10.1126/stke.3882007tw186]
 |  Abstract »

PERSPECTIVES
Immunology
Regulation of Interferon Production by RIG-I and LGP2: A Lesson in Self-Control

Damien Vitour and Eliane F. Meurs (1 May 2007)
Sci. STKE 2007 (384), pe20. [DOI: 10.1126/stke.3842007pe20]
 |  Abstract »  |  Full Text »  |  PDF »