Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Sci. STKE, 8 May 2007
Vol. 2007, Issue 385, p. pe22
[DOI: 10.1126/stke.3852007pe22]

PERSPECTIVES

Cdc37 Regulation of the Kinome: When to Hold ‘Em and When to Fold ‘Em

Larry M. Karnitz1* and Sara J. Felts2

1Department of Molecular Pharmacology and Experimental Therapeutics and
2Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

Abstract: Although massive genome sequencing efforts have identified the protein kinases encoded by several eukaryotic genomes and proteomic analyses have begun to determine the kinases expressed in a cell, there is still much to learn about the additional cellular events that shape eukaryotic kinomes. Large-scale analyses in Saccharomyces cerevisiae have indicated that a relatively small subset of kinases requires chaperoning by heat shock protein 90 (Hsp90). However, new evidence suggests that most kinases do require chaperoning and, furthermore, that Cdc37, a chaperone that has Hsp90-dependent and -independent functions, serves as the chaperone for a large portion of the yeast kinome.

*Corresponding author. 200 First Street SW, Guggenheim 13, Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. Telephone, 507-284-3124; fax, 507-284-3906; e-mail, karnitz.larry{at}mayo.edu

Citation: L. M. Karnitz, S. J. Felts, Cdc37 Regulation of the Kinome: When to Hold ‘Em and When to Fold ‘Em. Sci. STKE 2007, pe22 (2007).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells.
R. Rao, W. Fiskus, Y. Yang, P. Lee, R. Joshi, P. Fernandez, A. Mandawat, P. Atadja, J. E. Bradner, and K. Bhalla (2008)
Blood 112, 1886-1893
   Abstract »    Full Text »    PDF »

Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)