Systems Pharmacology of Arrhythmias

Seth I. Berger, Avi Ma'ayan, Ravi Iyengar*

*To whom correspondence should be addressed. E-mail: Ravi.Iyengar{at}mssm.edu

This PDF file includes:

• Fig. S1. Overview of data integration and analysis.
• Fig. S2. Comparison of node connectivity in networks created by nearest-neighbor expansion or through module distance score based on MFPT.
• Fig. S3. Average shortest path to seed node as a function of network size.
• Fig. S4. Network size distribution.
• Fig. S5. ROC curve for classification of disease genes.
• Fig. S6. Network modular versus nonmodular diseases: Leave-one-out recovery rate distribution.
• Fig. S7. The use of the LQTS neighborhood rankings to identify SNPs in the QTSCD GWAS.
• Fig. S8. The distribution of drug targets.
• Fig. S9. Methodology for integrating systems pharmacology and personalized medicine.
• Fig. S10. The distribution of number of drugs associated with each adverse event report in AERS.
• Fig. S11. Fraction of AERS events involving neighborhood drugs.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 350 KB

Other Supplementary Material for this manuscript includes the following:

• Table S1. Ranked nodes in the LQTS neighborhood (Excel file).
• Table S2. Table of diseases and network overlap and recovery rate (Excel file).
• Table S3. Drugs used to evaluate the LQTS neighborhood (Excel file).
• Table S4. Ranking of kinase inhibitors based on their targets in LQTS neighborhood (Excel file).

.[Download Tables S1 to S4 (Compressed)]

Technical Details

Format: Microsoft Excel

Size: 585 KB (compressed); 1.9 MB (decompressed)

For files packaged as a compressed archive, in *.zip format; users should download the compressed file to their machine and decompress the file on their local hard drive, using the following instructions.

Instructions for downloading and decompressing files:

1. Create a temporary folder on your machine's hard drive.

2. Save the compressed archive to the temporary folder you created, using the links above.

3. Decompress the compressed file in the temporary folder using decompression software, such as WinZip (Windows; www.winzip.com) or StuffIt Expander (Windows and Mac; www.stuffit.com).

© 2010 American Association for the Advancement of Science