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Sci. Signal., 27 April 2010
[DOI: 10.1126/scisignal.2000911]

Supplementary Materials for:

Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy

Christina H. Eng, Ker Yu, Judy Lucas, Eileen White, Robert T. Abraham*

*To whom correspondence should be addressed. E-mail: Robert.Abraham{at}pfizer.com

This PDF file includes:

  • Fig. S1. Measurement of autophagic flux.
  • Fig. S2. Characterization of CCM.
  • Fig. S3. CO2, H2O2, NO, and lactate do not promote autophagy.
  • Fig. S4. Induction of autophagy is unaffected by intracellular Ca2+ buffering or inhibitors of mRNA transcription and translation.
  • Fig. S5. Atg5 or Ulk1 knockdown enhances TNF-α sensitivity.

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Citation: C. H. Eng, K. Yu, J. Lucas, E. White, R. T. Abraham, Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy. Sci. Signal. 3, ra31 (2010).

© 2010 American Association for the Advancement of Science

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