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Sci. Signal., 8 June 2010
[DOI: 10.1126/scisignal.2000549]

Supplementary Materials for:

Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation

Yu Chen, Yongli Yao, Yuka Sumi, Andrew Li, Uyen Kim To, Abdallah Elkhal, Yoshiaki Inoue, Tobias Woehrle, Qin Zhang, Carl Hauser, Wolfgang G. Junger*

*To whom correspondence should be addressed. E-mail: wjunger{at}bidmc.harvard.edu

This PDF file includes:

  • Fig. S1. Colocalization of FPR and TTYH3 in human PMNs.
  • Fig. S2. Effects of blockers of ATP release on the ability of PMNs to hydrolyze
    extracellular ATP.
  • Fig. S3. Effects of blockers of ATP release on ATP-induced Ca2+ mobilization.
  • Fig. S4. Knockdown of P2Y2 and TTYH3.
  • Fig. S5. Colocalization of P2Y2 and FPR.
  • Descriptions of movies S1 and S2.
  • Reference

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 284 KB

Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.qt format).
    Z-stack view of a dHL-60 cell cotransfected with plasmids encoding P2Y2-ECFP (green) and FPR-EYFP (red).
  • Movie S2 (.qt format).
    A 3D view of a dHL-60 cell cotransfected with plasmids encoding P2Y2-ECFP (green) and FPR-EYFP (red).

Citation: Y. Chen, Y. Yao, Y. Sumi, A. Li, U. K. To, A. Elkhal, Y. Inoue, T. Woehrle, Q. Zhang, C. Hauser, W. G. Junger, Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation. Sci. Signal. 3, ra45 (2010).

© 2010 American Association for the Advancement of Science


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