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Sci. Signal., 29 June 2010
[DOI: 10.1126/scisignal.2000724]

Supplementary Materials for:

Origins and Diversification of a Complex Signal Transduction System in Prokaryotes

Kristin Wuichet and Igor B. Zhulin*

*To whom correspondence should be addressed. E-mail: ijouline{at}

This PDF file includes:

  • Table S1. Chemotaxis and motility components across 450 genomes.
  • Table S2. MAC systems.
  • Table S3. HKIII systems.
  • Table S4. Sensor domain diversity of two-component and chemotaxis systems.
  • Table S5. Domain architecture query sensitivities.
  • Fig. S1. Maximum likelihood trees built from CheA, CheB, and CheR multiple sequence alignments.
  • Fig. S2. Chemotaxis System Classification Step 1: Identifying coevolving CheA (A), CheB (B), and CheR (R) sequences.
  • Fig. S3. Chemotaxis System Classification Step 2: Defining classes using phylogenomic markers.
  • Fig. S4. Maximum likelihood tree built from a concatenated CheA-CheB-CheR multiple sequence alignment of CheA-CheB-CheR proteins.
  • Fig. S5. Chemotaxis System Classification Step 3: Assigning unclassified CheA (A), CheB (B), and CheR (R) sequences to chemotaxis system classes.
  • Fig. S6. Chemotaxis System Classification Step 4: Assigning CheC (C), CheD (D), CheV (V), CheW (W), CheX (X), and CheZ (Z) sequences to chemotaxis classes.
  • Fig. S7. Maximum likelihood trees built from individual CheC, CheD, CheV, CheW, and CheZ multiple sequence alignments.
  • Fig. S8. Multiple sequence alignment of the putative MAC1 methylation region.
  • Fig. S9. Multiple sequence alignment of the putative MAC2 methylation region.
  • Fig. S10. Multiple sequence alignment of the HKIII phosphotransfer and HATPase regions.
  • References

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Other Supplementary Material for this manuscript includes the following:

Citation: K. Wuichet, I. B. Zhulin, Origins and Diversification of a Complex Signal Transduction System in Prokaryotes. Sci. Signal. 3, ra50 (2010).

© 2010 American Association for the Advancement of Science

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