A Direct and Functional Interaction Between G_o and Rab5 During G Protein–Coupled Receptor Signaling

Vladimir Purvanov, Alexey Koval, Vladimir L. Katanaev*

*To whom correspondence should be addressed. E-mail: vladimir.katanaev{at}uni-konstanz.de

This PDF file includes:

• Fig. S1. Reduction in the abundance of Rab5 results in reduced Wg signaling.
• Fig. S2. Fz1 simulates endocytosis in a Wg- and Gα_o-dependent manner.
• Fig. S3. Biochemical interactions of Rab5, Gα_o, Gβγ, and Fz1.
• Fig. S4. Analysis of the localization of Gα_o and Rab5 in hemocytes from flies of different genotypes.
• Fig. S5. Fz1 and Fz2 relocalize Rab5 into intracellular puncta in salivary glands.

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