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Sci. Signal., 12 October 2010
[DOI: 10.1126/scisignal.2001077]

Supplementary Materials for:

Sexually Dimorphic Actions of Glucocorticoids Provide a Link to Inflammatory Diseases with Gender Differences in Prevalence

Danielle Duma, Jennifer B. Collins, Jeff W. Chou, John A. Cidlowski*

*To whom correspondence should be addressed. E-mail: cidlows1{at}niehs.nih.gov

This PDF file includes:

  • Methods
  • Fig. S1. Nascent RNA analysis of glucocorticoid-regulated genes.
  • Fig. S2. Comparison of male and female rat liver cross sections stained with hematoxylin and eosin.
  • Fig. S3. Comparison of glucocorticoid receptor mRNA and protein abundance and binding to [3H]dexamethasone in male and female rat liver.
  • Fig. S4. Comparison of glucocorticoid receptor mRNA and protein abundance in the liver of female rats in different phases of estrous cycle.
  • Fig. S5. Sexually dimorphic regulation of gene expression by glucocorticoids in isolated hepatocytes.
  • Fig. S6. Sexually dimorphic regulation of gene expression by glucocorticoids in mouse liver.
  • Fig. S7. Analyses of gender-specific expression patterns of nuclear receptor coregulators.
  • Fig. S8. Analysis of dose-response curves for dexamethasone in male and female rat livers.
  • References

[Download Corrected PDF]

CORRECTED 26 OCTOBER 2010: The authors inadvertently included the wrong graph for panel B of Figure S8 of the Supplementary Materials. In the legend, the graph was described as showing the mRNA abundance of FkBp5, but graph showed that of Gucy2c.

Technical Details

Format: Adobe Acrobat PDF

Size: 377 KB

The original, uncorrected version can be downloaded here.


Other Supplementary Material for this manuscript includes the following:

  • Table S1. List of glucocorticoid-responsive genes in male and female rat liver for each pattern of gene expression identified by EPIG analyses (Microsoft Excel format).
  • Table S2. List of genes contained in gene networks generated by IPA for each pattern of gene expression (Microsoft Excel format).
  • Table S3. List of common, male-specific, and female-specific glucocorticoidregulated genes involved in inflammatory disorders (Microsoft Excel format).
  • Table S4. List of gender-specific nuclear receptor co-regulators (Microsoft Excel format).

Citation: D. Duma, J. B. Collins, J. W. Chou, J. A. Cidlowski, Sexually Dimorphic Actions of Glucocorticoids Provide a Link to Inflammatory Diseases with Gender Differences in Prevalence. Sci. Signal. 3, ra74 (2010).

© 2010 American Association for the Advancement of Science


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