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Sci. Signal., 14 December 2010
[DOI: 10.1126/scisignal.2001056]

Supplementary Materials for:

A Conceptual Molecular Network for Chemotactic Behaviors
Characterized by Feedback of Molecules Cycling Between the
Membrane and the Cytosol

Mikiya Otsuji,* Yuya Terashima, Shuji Ishihara, Shinya Kuroda, Kouji Matsushima*

*To whom correspondence should be addressed. E-mail: mohtsuji-tky{at}umin.ac.jp (M.O.); koujim{at}m.u-tokyo.ac.jp (K.M.)

This PDF file includes:

  • Section 1. Analytical examination of the instabilities of the MCRD system.
  • Section 2. Simulations.
  • Section 3. Observation of chemotaxing cells.
  • Section 4. MCRD system with restriction mechanism.
  • References
  • Fig. S1. Analysis of chemotaxing cells.
  • Fig. S2. A system that generates both SSA and S&C patterns.
  • Fig. S3. Instability-2 and Instability-3.
  • Fig. S4. An MCRD system with an infinitely large Dc.
  • Fig. S5. Stable single axis with oscillation (SSAo).
  • Fig. S6. The 3S-MCRD system with a restriction mechanism.
  • Fig. S7. Competition between two peaks by Instability-1 in the S&C pattern.
  • Fig. S8. Dependency of the growth rate of instabilities on the number of peaks.
  • Fig. S9. Chemotaxing cells with multiple unstable pseudopods.
  • Fig. S10. Chemotaxing cells exhibiting a seesaw pattern of migration.
  • Fig. S11. Simulations for understanding right-left bias.
  • Table S1. Parameter values used in computation for verification of analysis.
  • Table S2. Parameter values used in the simulations.
  • Descriptions of Movies S1 to S3.

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Technical Details

Format: Adobe Acrobat PDF

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). Chemotaxing cells.
  • Movie S2 (.mov format). S&C behavior generated by the 2S-MCRD system.
  • Movie S3 (.mov format). S&C behavior generated by the 3S-MCRD system.

Technical Details

Format: Quicktime Movie

File Sizes: 1,424 KB (Movie S1); 1,825 KB (Movie S2); 1,974 KB (Movie S3)


Citation: M. Otsuji, Y. Terashima, S. Ishihara, S. Kuroda, K. Matsushima, A Conceptual Molecular Network for Chemotactic Behaviors Characterized by Feedback of Molecules Cycling Between the Membrane and the Cytosol. Sci. Signal. 3, ra89 (2010).

© 2010 American Association for the Advancement of Science


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