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Sci. Signal., 1 February 2011
[DOI: 10.1126/scisignal.2001249]

Supplementary Materials for:

Wnt Signaling Regulates Hepatic Metabolism

Hongjun Liu, Maria M. Fergusson, J. Julie Wu, Ilsa I. Rovira, Jie Liu, Oksana Gavrilova, Teng Lu, Jianjun Bao, Donghe Han, Michael N. Sack, Toren Finkel*

*To whom correspondence should be addressed. E-mail: finkelt{at}nih.gov

This PDF file includes:

  • Fig. S1. Deletion of hepatic β-catenin does not alter serum insulin concentration.
  • Fig. S2. Quantification of FoxO1 subcellular localization.
  • Fig. S3. Insulin tolerance tests (ITTs) in flox/flox β-catenin mice after injection with adenoviruses encoding GFP or Cre recombinase.
  • Fig. S4. Subcellular localization of FoxO1 in primary hepatocytes after insulin stimulation.
  • Fig. S5. Deletion of β-catenin decreases the mRNA abundance of FoxO1 transcriptional targets.
  • Fig. S6. Knockdown of FoxO1 decreases the mRNA abundance of β-catenin transcriptional targets.
  • Fig. S7. Wnt stimulation increases binding of β-catenin to the G6PC promoter.
  • Fig. S8. Wnt3a stimulates hepatocyte oxygen consumption.
  • Fig. S9. Effects of glucagon stimulation on the abundance of mRNAs encoding Wnt ligands.
  • Fig. S10. The effect of β-catenin on the abundance of mRNAs encoding lipid enzymes and on triglyceride concentrations.

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Citation: H. Liu, M. M. Fergusson, J. J. Wu, I. I. Rovira, J. Liu, O. Gavrilova, T. Lu, J. Bao, D. Han, M. N. Sack, T. Finkel, Wnt Signaling Regulates Hepatic Metabolism. Sci. Signal. 4, ra6 (2011).

© 2011 American Association for the Advancement of Science


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