Mitochondrial Membrane Potential Is Required for MAVS-Mediated Antiviral Signaling

Takumi Koshiba,* Kai Yasukawa, Yusuke Yanagi, Shun-ichiro Kawabata

*To whom correspondence should be addressed. E-mail: koshiba{at}kyudai.jp

This PDF file includes:

• Fig. S1. Suppression of IFN-β production in Mfns-dm MEFs in response to polyI:C.
• Fig. S2. HEK 293 cells and wild-type MEFs stained with MitoProbe JC-1.
• Fig. S3. CCCP inhibits the MDA-5–dependent production of IFN-β in a dose-dependent manner.
• Fig. S4. Analysis of cytochrome c release and caspase-3 activation in wild-type MEFs.
• Fig. S5. CCCP-treated cells are unaffected by extracellular polyI:C or LPS.
• Fig. S6. CCCP inhibits antiviral signaling in HEK 293 cells.
• Fig. S7. UCP-2 inhibits MAVS-mediated activation of the NF-κB reporter.
  

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© 2011 American Association for the Advancement of Science