TWIK-1 Two-Pore Domain Potassium Channels Change Ion Selectivity and Conduct Inward Leak Sodium Currents in Hypokalemia

Liqun Ma, Xuexin Zhang, Haijun Chen*

*To whom correspondence should be addressed. E-mail: hchen01{at}albany.edu

This PDF file includes:

• Text
• Fig. S1. TWIK-1 WT K⁺ channels show altered ion selectivity and conduct inward leak Na⁺ currents in subphysiological [K⁺]_o.
• Fig. S2. Effects of removing 5 mM [K⁺]_o on TWIK-1 WT K⁺ channels and five other types of K2P channels.
• Fig. S3. Effects of removing 5 mM [K⁺]_o on THIK-1 WT and THIK-1•I112T mutant channels.
• Table S1. Reversal potentials and whole-cell currents of TWIK-1 WT and TWIK-1•K274E channels in 5 and 0 mM [K⁺]_o.
• References

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