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Sci. Signal., 7 June 2011
[DOI: 10.1126/scisignal.2001726]

Supplementary Materials for:

TWIK-1 Two-Pore Domain Potassium Channels Change Ion Selectivity and Conduct Inward Leak Sodium Currents in Hypokalemia

Liqun Ma, Xuexin Zhang, Haijun Chen*

*To whom correspondence should be addressed. E-mail: hchen01{at}albany.edu

This PDF file includes:

  • Text
  • Fig. S1. TWIK-1 WT K+ channels show altered ion selectivity and conduct inward leak Na+ currents in subphysiological [K+]o.
  • Fig. S2. Effects of removing 5 mM [K+]o on TWIK-1 WT K+ channels and five other types of K2P channels.
  • Fig. S3. Effects of removing 5 mM [K+]o on THIK-1 WT and THIK-1•I112T mutant channels.
  • Table S1. Reversal potentials and whole-cell currents of TWIK-1 WT and TWIK-1•K274E channels in 5 and 0 mM [K+]o.
  • References

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Citation: L. Ma, X. Zhang, H. Chen, TWIK-1 Two-Pore Domain Potassium Channels Change Ion Selectivity and Conduct Inward Leak Sodium Currents in Hypokalemia. Sci. Signal. 4, ra37 (2011).

© 2011 American Association for the Advancement of Science


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